Publications

2019

Lingaraju, M., Johnsen, D., Schlundt, A., Langer, L.M., Basquin, J., Sattler, M., Jensen, T.H., Falk, S.* and Conti, E.* (2019). The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature Communications 10, 3393. PMID: 31358741

2018

Gerlach, P., Schuller, J.M., Bonneau, F., Basquin, J., Reichelt, P., Falk, S.and Conti, E. (2018). Distinct and evolutionary conserved structural features of the human nuclear exosome complex. eLife 2018; 7:e38686. PMID: 30047866 

Schuller, J.M.*, Falk, S.*, Fromm, L., Hurt, E. and Conti, E. (2018). Structure of the nuclear exosome captured on a maturing pre-ribosome. Science Apr 13; 360, 219-222 PMID: 29519915

2017

Falk, S., Tants, J.-N., Basquin, J., Thoms, M., Hurt, E., Sattler, M., and Conti, E. (2017). Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53. RNA 23, 1780–1787. PMID: 28883156 

Fromm, L., Falk, S., Flemming, D., Schuller, J.M., Thoms, M., Conti, E., Hurt, E. (2017). Reconstitution of  the complete pathway of  ITS2 processing at the pre-ribosome. Nature Communications 8, 1787. PMID: 29176610

Falk, S., Ebert, J., Kögel, A, Bonneau, F. and Conti, E. (2017). Mpp6 incorporation into the nuclear exosome contributes to RNA channeling through the Mtr4 helicase.Cell Reports 20, 2279–2286. PMID: 28877463 

2016

Falk, S.*, Finogenova, K.*, Melko, M., Benda, C., Lykke-Andersen, S., Jensen, T. H., and Conti, E. (2016). Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nature Communications 7, 13573 PMID: 27905398 

2015

Ozgur, S., Buchwald, G., Falk, S., Chakrabarti, S., Prabu, J.R., and Conti, E. (2015). The conformational plasticity of eukaryotic RNA-dependent ATPases. FEBS J. 282, 850–863. PMID: 25645110 

2014

Schuch, B., Feigenbutz, M., Makino, D. L., Falk, S., Basquin, C., Mitchell, P., and Conti, E. (2014). The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. EMBO J. 33, 2829–2846. PMID: 25319414

Falk, S.*, Weir, J. R.*, Hentschel, J., Reichelt, P., Bonneau, F., and Conti, E. (2014). The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities.Molecular Cell 55, 856–867. PMID: 25175027

Lauinger, L., Diernfellner, A., Falk, S., and Brunner, M. (2014). The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa. Nature Communications 5, 3598–10. PMID: 24710172

2013

van Noort, V., Bradatsch, B., Arumugam, M., Amlacher, S., Bange, G., Creevey, C., Falk, S., Mende, D. R., Sinning, I., Hurt, E., and Bork, P. (2013). Consistent mutational paths predict eukaryotic thermostability. BMC Evol. Biol. 13, 7. PMID: 23305080

2011

Pietrosiuk, A., Lenherr, E. D., Falk, S., Bönemann, G., Kopp, J., Zentgraf, H., Sinning, I., and Mogk, A. (2011). Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J. Biol. Chem. 286, 30010–30021. PMID: 21733841

2010

Falk, S., and Sinning, I. (2010). The C-terminus of Alb3 interacts with the chromodomains 2 and 3 of cpSRP43. J. Biol. Chem. 285, author reply le26–8. PMID: 21186296

Falk, S., and Sinning, I. (2010) cpSRP43 is a novel chaperone specific for light-harvesting chlorophyll a,b-binding proteins. J. Biol. Chem. 285, 21655–21661. PMID: 20498370

Falk, S., Ravaud, S., Koch, J., and Sinning, I. (2010). The C-terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane. J. Biol. Chem. 285, 5954–5962. PMID: 20018841